SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27

Gallagher ER, Holzbaur ELF. SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27. Autophagy. 2023 Nov;19(11):3029-3030. doi: 10.1080/15548627.2023.2210943. Epub 2023 May 16. PMID: 37194327; PMCID: PMC10548893.

Abstract

SQSTM1/p62: Sequestosome-1; HSP27: Heat shock protein 27; LLPS: liquid-liquid phase separation; iPSC: induced pluripotent stem cell; PB1: Phox and Bem1p; FRAP: fluorescence recovery after photo-bleaching; ATG: autophagy-related; ALS: amyotrophic lateral sclerosis.