El Khatib M, Motlagh AO, Beyer JN, Troxler T, Allu SR, Sun Q, Burslem GM, Vinogradov SA. Direct Measurements of FLASH-Induced Changes in Intracellular Oxygenation. Int J Radiat Oncol Biol Phys. 2023 Sep 18:S0360-3016(23)07931-2. doi: 10.1016/j.ijrobp.2023.09.019. Epub ahead of print. PMID: 37729972.
Abstract
Purpose: The goal of our study was to characterize the dynamics of intracellular oxygen during application of radiation at conventional (CONV) and FLASH dose rates and obtain evidence for or against the oxygen depletion hypothesis as a mechanism of the FLASH effect.