Green AI, Burslem GM. Degradation of NSD3: What to Myc of it all? Cell Chem Biol. 2022 Mar 17;29(3):356-357. doi: 10.1016/j.chembiol.2022.03.005. PMID: 35303440.
Abstract
Preventing uncontrolled gene expression is a powerful therapeutic strategy for the treatment of cancers. In this issue of Cell Chemical Biology, Xu et al. (2022) describe a series of proteolysis targeting chimeras that induce the degradation of NSD3 and suppress cMyc-related oncogene transcription in a model of acute myeloid leukemia.