Zhao J, Pan B, Fina M, Huang Y, Shimogawa M, Luk KC, Rhoades E, Petersson EJ, Dong DW, Kashina A. α-Synuclein arginylation in the human brain. Transl Neurodegener. 2022 Apr 8;11(1):20. doi: 10.1186/s40035-022-00295-0. PMID: 35395956; PMCID: PMC8991655.
Abstract
Background: Alpha-synuclein (α-syn) exhibits pathological misfolding in many human neurodegenerative disorders. We previously showed that α-syn is arginylated in the mouse brain and that lack of arginylation leads to neurodegeneration in mice.